Hemagglutinin (influenza)
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Hemagglutinin, as depicted in a simplified molecular model.
Hemagglutinin (HA) in action. HA binds sugars (green), then the cell releases acid molecules making HA refolding in a different way. Red peptide is the fusion peptide, that locks virus near the cell membrane. Yellow portion produces fusion between the two membranes.
Hemagglutinin is a spike-shaped virus surface protein made of two chain types. Blue: subunit for binding of specific human cell surfaces sugars. Orange: subunit for triggering response (PDB code: 1ruz). (
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Influenza hemagglutinin (HA) or haemagglutinin (British English) is a type of hemagglutinin found on the surface of the influenza viruses. It is an antigenic glycoprotein. It is responsible for binding the virus to the cell that is being infected.
The name "hemagglutinin" comes from the protein's ability to cause red blood cells (erythrocytes) to clump together ("agglutinate") in vitro [1].
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